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TIGR may supplement CRISPR by providing more refined DNA targeting

The tandem interspaced guide RNA is primarily found in viruses—unlike CRISPR, which is bacterial in origin—and is smaller than CRISPR, making it easier to deliver into cells. The TIGR-Tas system appears to read both sides of the DNA double helix and opens a smaller segment of DNA for repairs, improving the precision of single letter modification.

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