Grosse Île, the quarantine island of the Port of Quebec

The canal carried germs as well as goods

In 1832, North America’s first cholera epidemic spread inland by way of the Erie Canal, carried by immigrants arriving on ships. Fearful towns barred passengers from disembarking, yet cholera, smallpox, and other diseases still traveled the waterway.

Poems and stories inscribed on the walls of a US immigration island

What Ellis Island was to the East Coast, Angel Island was to the West. Just off the coast of San Francisco, this processing center became a detention center for those targeted by exclusionary immigration laws. Click here to read some of the stories left by the detained.

40% of Americans have ancestors who immigrated via Ellis Island

For over 60 years, Ellis Island was the gateway to America, processing millions of immigrants seeking a new life. While many passed through with ease, others faced rigorous medical exams, legal scrutiny, and even deportation. Learn how this small island shaped generations of American families.

Disappointment Island

A shipwreck. A freezing island. No trees. No help. Just 16 sailors, stranded for 8 months on Disappointment Island in 1907.

In 1865, Hawaii's king authorized forcible removal, quarantining of those with leprosy

King Kamehameha V authorized the removal of anyone with leprosy symptoms and for them to be placed in a medical facility later maintained by the Catholic Church on Moloka'i, Hawaii's fifth largest island. Patients weren't allowed to transfer to other medical facilities until 1969.

America had a national leprosarium—a leper colony—in Louisiana until 1999

Public health officials forcibly sent those diagnosed with leprosy to the Louisiana Leper Home in Carville, first founded in 1894. Listen to an interview about this site, its evolution, and how its residents advocated for themselves—including regaining the right to vote.

Irish music became popular in the US during the 19th century

The influx of Irish immigrants in the mid-1800s, driven by starvation and abysmal employment opportunities, led to a significant Irish-American culture, especially in urban hubs such as New York, Boston, Philadelphia, Chicago, and San Francisco.

A Native American city in present-day Illinois once rivaled the size of medieval London

Around 1100, the city of Cahokia, the largest Mississippian settlement, reached a population of 15,000 to 20,000. Located across the Mississippi River from present-day St. Louis, it featured massive earthen pyramids and a central plaza the size of 35 football fields.

Maryland required cholera researchers to fly a yellow warning flag—signifying quarantine dangers in the 1970s

University of Maryland Hospital researchers intentionally infected volunteers with the cholera bacterium in the late 1970s to further their understanding of the disease. They proceeded with this work following the recommendation of a US government panel. (Some users may encounter a paywall.)

During the COVID-19 pandemic, readers returned to Camus' 'The Plague'

The 1947 novel, about a city in Algeria that enacts a city-wide quarantine to battle a deadly outbreak, captured readers' attention in the early months of 2020. In the UK, over 2,000 copies of the book were sold in March of that year, over six times what it had sold the month before.

Europeans' arrival to America brought disease to Indigenous populations

Indigenous people lived in the Americas for centuries before the arrival of the first Europeans in the 15th century. Their arrival was disastrous for Native tribes; in addition to being enslaved and losing their land, they had no natural immunity to the diseases brought by colonists. Eventually, up to 95% of the Native American population was killed by illnesses including typhus, chickenpox, and cholera, an event now known as the Great Dying.

Pheasant Island is controlled by both the Spanish and the French

The two-acre plot of land is a condominium—a territory shared by two countries. Pheasant Island (which, curiously, is not home to pheasants) is a holdover from the end of the Thirty Years' War between France and Spain, when it was designated as a neutral area dividing the countries.

Paris and Boston were redesigned partly to combat cholera's spread

Georges-Eugène "Baron" Haussmann, who oversaw Paris's redesign in the 1800s, replaced many of the city's narrow streets with wide boulevards. This was done at least in part to bring more air and light into the city to help control cholera. Architect Arthur Gilman redeveloped Boston's Back Bay to similarly combat cholera, among other reasons.

Read an account of what life was like in America's national leprosarium—its leper colony

José Ramirez Jr. shares an account of his eight years at the 300-acre national leprosarium in Carville, Louisiana, from 1968 through the mid-1970s. Mostly staffed by nuns with nursing degrees, this facility was home to hundreds of people at a time, and it's also the site where they were required to be buried.

Mapping Michigan's shipwrecks

For centuries, the Great Lakes have provided vital access to the Midwest from the Atlantic Ocean, allowing the establishment of key trading outposts and ultimately the growth of major cities in the region. An estimated 6,000 vessels were lost on the Great Lakes with approximately 1,500 of these ships located in Michigan waters. Explore the deadly legacy of the region with resources pulled together by the Michigan History Center.

Null Island: the most real fictional island you can almost visit

This article explores Null Island, which can be found on most maps at exactly 0° latitude and 0° longitude. If someone were to paddle out to those coordinates, they'd find themselves in front of a buoy named Soul off the west coast of Africa. User...

It's likely a myth that Ellis Island inspectors changed immigrants' names, and historians say the errors actually happened overseas.

Niagara Falls was a key Underground Railroad crossing point

In the mid-1800s, the Suspension Bridge near Niagara Falls connected the US to Canada and served as a frequent crossing location for people escaping slavery via the Underground Railroad.

Dr. William Gorgas eradicated yellow fever in Panama, crucial to canal construction

The disease was one of the factors hampering the French effort to build the canal. Gorgas' experience elsewhere in the Caribbean had taught him that good drainage and quaranting patients were essential, and he would eventually apply mosquito prevention tactics on a mass scale.

In the 1800s, the carcasses of the many horses that died transporting city residents were dumped in a bay in New York City.

Play 17th-century death roulette

Before modern science and medicine, death was much harder to escape. Using real mortality records from London's Dreadful Visitation–a collection of all the Bills of Mortality from 1665–this interactive game gives you an idea of what may have possibly killed you during the Great Plague. Grow your appreciation for life today as you stumble upon causes of death like “livergrown” and “drowned at St. Katharine’s by the Tower”.

Cholera went global thanks to global trade

The first cholera pandemic grew from an outbreak in India, in 1817. Scientists suggest it spread from there throughout the continent and onward to Africa, Russia and Europe through the poop of traders.

Read excerpted accounts from some of the 8,000 residents with leprosy on Moloka'i

Accounts preserved by the Kalaupapa National Historical Park describe how residents felt about being sent to live in this remote location and knowing they would never be allowed to leave. In 2012, 20 residents with the disease continued to voluntarily live in the area.

The cholera bacteria was first isolated in 1854—but the discovery was largely ignored

The pathogen was isolated by the Italian physician Filippo Pacini in Florence, Italy, though his discovery was largely ignored in favor of the popular miasma—bad air—theory of disease at the time. The pathogen was separately isolated about three decades later by German microbiologist Robert Koch.

The Irish 'sláinte!' spread outside the country thanks to immigration

The toast has spread globally because of the waves of Irish immigration in the 19th and 20th centuries. It’s not uncommon to find an Irish pub outside of Ireland, and if you step inside, you’re lucky to hear someone offer a hearty “sláinte!”

Volcanic activity may have triggered the Black Death by spewing gases that led to crop failures in Europe, thus forcing the import of grain ships with plague-infested fleas.

Null Island is located at a latitude and longitude of 0°

A buoy denotes the fictional island where the Prime Meridian intersects with the equator in the Atlantic Ocean. Nations had disagreed on where the "origin" of world maps should be located until the Prime Meridian and Greenwich Mean Time were established in 1884.

In 1892, two scientists purposefully infected themselves with cholera bacteria

When they became ill—one with mild diarrhea and the other with severe cholera—researchers pointed to that as proof that the pathogen caused the disease.

Irish immigrants deserted the US Army to fight for Mexico

During the Mexican-American War, hundreds of Irish Catholic immigrants—facing discrimination in the US Army—defected to Mexico and formed the Saint Patrick’s Battalion. Though many were captured and executed, they remain honored as heroes in Mexico.

...and allowed newly arrived European immigrants to maintain their cultures

19th-century public schools often included Protestant spiritual instruction, something that was disturbing for Catholic immigrants from Ireland, Italy, Poland, and elsewhere, who found homes in neighborhood “parochial” schools.

The Erie Canal fueled a surge in westward settlement

By providing cheap, reliable transport to the interior, the canal made western lands more accessible. Farmers, traders, and immigrants moved into the Great Lakes region, accelerating population growth.

There were 23 reported cruise ship outbreaks of gastrointestinal illness in 2025—something that happens often enough that there's a whole program at the US CDC devoted to tracking them.

Cholera was called the 'Blue Death'

In the mid-1800s—when John Snow identified cholera in London—the disease was known simply as the "Blue Death." That's because blood would thicken in patients' veins when they were struggling with extreme dehydration. As a result, their skin would turn a blueish hue as their blood was starved of oxygen.

Mapping the known ports involved in the trans-Atlantic slave trade

Based on historical logs, this interactive maps shows info from various ports of departure and arrival during the height of the trans-Atlantic slave trade.

One Canadian town operates a polar bear jail

The town of Churchill has a population of 850 humans and just as many polar bears. In an effort to prevent hungry bears from breaking into homes or attacking residents, the town began imprisoning them for 30-day stints.

More than 4,000 people died from cholera in 2023

This global health threat sickened more than half a million people in 2023 and killed 4,007 people. That's a 71% increase in deaths as compared to a year earlier. (Report only offered in PDF format.)

Hear the story of a doctor who decided to flee Cuba with his family in 1963

In this StoryCorps conversation, Gustavo Mestas reflects on leaving the island with his family in 1963 and the difficult transition that followed—from treating patients in Cuba to picking tomatoes and cleaning motels while rebuilding a life in the US.

See the last known image of the Titanic afloat (1912)

Three days before the tragedy unfolded, this photo was taken by an Irish Jesuit priest who sailed with the ship for the first part of its journey from England to Ireland.

Indian Creek Village: the exclusive billionaire island

Off the coast of Miami lies an island called Indian Creek Village. Spanning around 300 acres, the island is home to a few dozen homes owned by celebrities, sports stars, and tech founders. Only residents and verified visitors can enter this private space, protected by its own police force. Listen to this podcast episode for more information about the private island and why the wealthy love it.

British Columbia's 'Infinite Coast' is a hidden travel gem

The long expanse of Pacific coast north of the US border includes Victoria, Vancouver Island, the Great Bear Rainforest, fjords, whale watching, and 50 First Nations that manage the coastline. This site presents the region in an engaging interactive format to attract travelers looking for lesser-known areas of natural beauty.

Hollywood's efficient response to the Spanish flu made it a filmmaking destination

In 1918, the Great Influenza epidemic killed more than 675,000 Americans. Los Angeles was one of the first cities to shut down movie theaters, most of which were independently owned and couldn’t afford the revenue loss. The results were twofold: the quick response meant that Hollywood could bounce back faster than other film hubs, and it also contributed to the rise of vertical integration as studios stepped in to purchase the flailing theaters.

The wonderfully named Vibrio diabolicus is a cousin of the cholera-causing bacterium

This bacterium, which belongs to the same genus as the cholera bacterium, was initially isolated from deep-sea hydrothermal fields. It was sampled from water that was scooped up during a French-American cruise in October 1991.

After the World Trade Center attacks, all bridges and tunnels were closed, and civilian ships helped evacuate roughly half a million people from Manhattan.

How Guam became an island of snakes and spiders

The US territory of Guam has 40 times the number of spiders of nearby islands, and a voracious collection of snakes which has nearly emptied it of any native birds. Researchers took it upon themselves to count the species and determine what turned the island into such a haunt of arachnids and serpents, where walking into the woods can mean navigating endless layers of spider webs. Find out more here.

Niagara’s frozen river once hosted winter carnivals

Before a 1912 collapse, winter ice bridges across the river were so thick that entrepreneurs built bars, photo studios, and entire carnival midways on the frozen surface.

Researchers discover a massive Lake Superior shipwreck

A 292-foot Whaleback ship, Barge 129, was found in Lake Superior 120 years after a storm sank it, the Great Lakes Shipwreck Historical Society said.

Explore the history of antibiotics with 'This Podcast Will Kill You'

The show blends medical history with storytelling and science. In Episode 50, the hosts trace the dramatic origins of antibiotics—from Fleming's moldy petri dish to Florey's wartime labs—and explore their lasting impact on health.

Cannes' Sainte-Marguerite was home to the 'Man in the Iron Mask'

Although his identity was never known, the man imprisoned under King Louis XIV and forced to wear a mask—reputedly made of iron, though likely to be velvet—was imprisoned on an island off the coast of Cannes.

How Guinness became a social media trend

In early 2024, an unexpected meme emerged on Instagram and TikTok: "splitting the G," where Guinness drinkers would attempt to take a first sip big enough to leave the remaining beer perfectly aligned with the middle of the "G" on a Guinness pint glass. This Vinepair article explores where the trend came from and how it took off.

Take a 3D underwater trip near the Great Barrier Reef

The Great Barrier Reef is the world's largest coral reef system, comprising more than 900 islands and almost 3,000 individual reefs. This video lets you tag along with divers as they explore the reef off the southern coast of Lady Elliot Island in full 3D (use the direction buttons in the upper left of the video, or your keypad).