Good morning. It's Saturday, Jan. 25, and in this weekend edition, we're covering promising results of a new weight-loss drug, a pair of pandas debuting in the nation's capital, and much more. First time reading? Join over 4 million intellectually curious readers. Sign up here.
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Dear Readers—
Tomorrow, many of you will see 1440's newest offering in your inbox—the Sunday Edition. Unlike our daily news-focused digests, our team of knowledge-obsessed curators will share a deeply researched summary of a fascinating theme or idea, plus a fun mix of additional resources to discover from 1440 Topics.
Delivered directly to your inbox, our Sunday Edition is designed to feed your curiosity and expand your knowledge—all by human editors, not algorithms. |
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Novo Nordisk's shares surged as much as 14% yesterday after the pharmaceutical giant released promising results from an early-stage trial of its new weight-loss drug, amycretin. The latest experimental once-a-week injection builds on the success of Novo Nordisk's existing weight-loss medications like Wegovy and Ozempic.
The Danish company found 125 obese and overweight adults who participated in the clinical trial lost around 22% of their body weight after 36 weeks. Similar to Wegovy and Ozempic (functionally the same drug, w/video), amycretin mimics a gut hormone known as GLP-1, which regulates appetite and feelings of fullness. Amycretin also stimulates a pancreas hormone called amylin, which controls appetite and regulates blood sugar. Relatedly, Novo Nordisk is working on a pill version of amycretin, which helped separate trial participants lose about 13% of their body weight in 12 weeks.
Roughly 30% of US adults are clinically overweight, while 40% of US adults are clinically obese, a risk factor for diabetes, heart disease, and more. See all data here. |
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Hamas to free four Israeli female soldiers today.
Their release is part of a ceasefire deal struck between Hamas and Israel. In exchange, Israel will free at least 200 imprisoned Palestinians. The swap will be the second such exchange after Hamas released three civilian hostages and Israel released 90 Palestinian prisoners last week. Israel will free 30 Palestinians in custody for every civilian hostage Hamas frees and 50 Palestinians in custody for every female Israeli soldier Hamas frees.
Storm Éowyn leaves one-third of Ireland without power.
Storm Éowyn (pronounced "Ay-oh-win") unleashed record-breaking winds of up to 114 mph across Ireland and the UK Friday, causing widespread disruption with over 725,000 homes in Ireland losing power. The wind speed beat a national record of 113 mph set in 1945. The storm is partly erupting from the same weather pattern that brought historic snowfall along the US Gulf Coast.
New giant pandas debut at Smithsonian National Zoo. (w/photos)
Male Bao Li (pronounced "BOW-lee") and female Qing Bao (pronounced "ching-BOW") made their official public debut at the National Zoo in Washington, DC. Bao Li and Qing Bao, both 3 years old, arrived in the US in October as part of a 52-year-old conservation partnership with China. View a live panda cam daily from 7 am to 7 pm ET here.
Trump, Vance address annual pro-life March for Life rally.
President Donald Trump delivered a remote address, while Vice President JD Vance spoke in person to the tens of thousands of people who attended the 52nd annual March for Life in Washington, DC, yesterday. The event is the country's largest pro-life demonstration. Trump's remarks came a day after he pardoned nearly two dozen activists convicted of blocking access to reproductive health clinics.
Judge bars Oath Keepers from entering Washington, DC.
A federal judge yesterday banned the antigovernment Oath Keepers militia group from entering Washington, DC, and the US Capitol without court approval. The group includes Oath Keepers founder Stewart Rhodes, who was released from prison this week and met with lawmakers after Trump pardoned roughly 1,500 defendants charged in the Jan. 6, 2021, storming of the US Capitol. |
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1440 Business & Finance: US Currency |
This upcoming week, we're taking a fascinating deep dive into the history, production, and lifecycle of US currency, from the cotton-linen blends of dollar bills to anticounterfeiting measures:
> Why paper money didn't appear until the Civil War.
> What those little ridges on quarters and dimes are for.
> A look at whether physical currency will ever disappear entirely.
... and much more. The newsletter comes out Thursday morning. Sign up here for free! |
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Toddler delivers tear-jerking speech at her mom and dad's wedding. (More, w/video)
College student shares his story of performing in the Ohio State band while battling stage 2 testicular cancer. (More, w/video)
Street artist leads nonprofit transforming Miami schools' walls into vibrant pieces of art. (More, w/photos)
Tanzanian entrepreneur turns old cement bags into solar-powered backpacks to help children read at night. (More)
Teen rides stranded scared horse to safety—14 miles out of burning canyon. (More) |
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In partnership with Energous |
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Today, we're sharing a story from reader Jeannie S. in Seattle, Washington.
"A co-worker recently left our current team for a different position. She was hired to replace me when I left 2 years ago for my own different position, and now I have returned. She shared her goodbye thoughts in an email to the team, and named qualities she admired about each of us. My named qualities were 'discipline, vulnerability, and fearlessness.' These are some pretty powerful words and qualities, and certainly not what I was expecting. What a great gift of kindness it is to uplift someone through simple and positive word choices."
What act(s) of kindness did you experience this week? Tell us here. |
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"We are all one. We're not as separate as we oftentimes think." |
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*Disclosure: This is a paid advertisement for Energous’ Regulation A offering. Please read the offering circular at invest.energous.com for additional information on the company and the risks factors to the offering. |
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