In partnership with

Good morning. It's Wednesday, Oct. 11, and we're covering a potentially widening conflict in the Middle East, a scientific first in the fight against avian flu, and much more. First time reading? Sign up here.


You share. We listen. As always, send us feedback at [email protected].

Need To Know

Israeli Airstrikes Intensify

Israel yesterday increased its mobilization of reservists to 360,000—the largest call-up since the country’s founding—as its military continued to launch airstrikes into the sealed-off Gaza Strip following Hamas' surprise attack in Israel Saturday. Israeli airstrikes destroyed Gaza's upscale Rimal neighborhood (see footage) and home to ministries of the Hamas-run government, and regained control of two dozen border towns. Hamas' rockets targeted Tel Aviv and the coastal town of Ashkelon. See the latest updates here.


The death toll in Israel has risen to more than 1,000, including at least 750 civilians and 14 Americans, with at least 2,600 wounded. At least 20 Americans are still unaccounted for in Israel, US President Joe Biden said yesterday. The Israeli military said it had found the bodies of roughly 1,500 Hamas assailants. In Gaza, at least 900 have died with 4,500 wounded. See the conflict in maps here.


Additionally, Israel said it intercepted four of 15 rockets launched from Lebanon, with which it shares a northern border, and that tanks from Israeli forces struck three Hezbollah observation posts. Hezbollah and Hamas are both backed by Iran. Israel also carried out artillery strikes in Syria, with which it shares a northeast border, after a Palestinian faction launched rockets into Israel. Observers say concerns are growing over a wider regional conflict.


US Secretary of State Antony Blinken is expected to arrive in Israel tomorrow in a show of support. The first plane carrying US ammunition arrived in Israel yesterday; Israel has asked the US for more weapons, including interceptors for its Iron Dome missile defense system (see visual overview). 


Flu-Resistant Chickens

UK scientists have successfully used gene-editing technology to create chickens that have some resistance to avian flu, offering a potential solution to prevent future outbreaks.


A lethal version, H5N1, has been damaging poultry farms globally in recent years. Since February 2022, the avian flu has directly or indirectly killed over 58 million chickens and turkeys in the US, including recent outbreaks in Utah and South Dakota. As of July, 685 outbreaks have been reported globally.


The researchers used CRISPR technology to alter two amino acids in a chicken protein called ANP32A, which is critical for bird flu virus replication. They then edited chicken embryos to produce 10 chickens with the altered protein before exposing the chickens (and 10 nonedited chickens) to a virus strain—only one gene-edited chicken became infected, compared to all nonedited chickens. When subjected to a viral dose 1,000 times higher, half of the gene-edited chickens were infected but had lower virus levels in their airways.


Regulatory testing and approvals are necessary before gene-edited chickens can be considered for consumption, with an estimated timeline of about 20 years.


FTX Deputy Testifies

Caroline Ellison, the former CEO of cryptocurrency hedge fund Alameda Research, testified in New York yesterday in the criminal fraud case against FTX founder Sam Bankman-Fried. Ellison, who pleaded guilty to seven charges in December, is cooperating with the prosecution.


The 28-year-old Ellison has revealed she was a key participant in the scam (see explainer), which led to the exchange's sudden downfall in November. Prosecutors have positioned her as their star witness, as she was both Bankman-Fried's top deputy and on-and-off girlfriend. Bankman-Fried has pleaded not guilty to all charges, including a separate campaign finance case set for March 2024.


Ellison claimed Bankman-Fried schemed to use billions of dollars of FTX deposits—in the exchange's native currency, FTT—to pad Alameda's balance sheet to better attract lenders to the exchange. She also shared details of their relationship, her compensation, and some of Bankman-Fried's political views. See highlights here.


If convicted, Bankman-Fried could be sentenced to life in prison. 

In partnership with CARIUMA

Ethics. Aesthetics. Our Fave Kicks.


What do the 1440 team, fashion-forward businesspeople, Olympic-medalist skateboarders, and world champion surfers have in common? They all wear the same shoes. Because even if typing doesn’t pump adrenaline quite like hanging 10, we all want to move in cloud-like comfort without sacrificing style or sustainabilitySo we sport Cariumas.


This fall, we're loving their OCA Low leather sneakers. Crafted with responsibly sourced premium materials, they come in classic neutrals (for any occasion) as well as their incredibly cool Hokusai collab. But don’t wait to grab a pair … the sustainable sneaker brand has over 40k 5-star reviews and regularly has to clear an over 109K-person waitlist. Turns out people like comfortable, long-lasting shoes that get compliments. Who knew?


Check out Cariuma today; find your perfect pair (or three) of Cariumas and enjoy an exclusive 20% off with code 144020.

Please support our sponsors!

In The Know

Sports, Entertainment, & Culture

In partnership with Apollo

> Las Vegas Aces take on New York Liberty tonight (9 pm ET, ESPN) in Game 2 of the WNBA Finals, with the Aces leading the best-of-five series 1-0 (More)

> Mary Lou Retton, 55-year-old iconic American Olympic gold medal-winning gymnast, in ICU with pneumonia (More)

> MLB Division Series continues; see latest schedule and playoff bracket (More) | Official World Golf Rankings won't accept LIV Golf tournaments in its player rankings (More)

From our partners: A wearable that trains your body to get more sleep and stress less. Apollo Neuro’s touch therapy technology was developed by neuroscientists and physicians to help calm your nerves and clear your mind, melting away stress using soothing vibrations for better sleep, relaxation, and focus. Tested across thousands of users in the clinic and in the real world, Apollo wearable users experience ~40% less stress and anxiety, up to 25% increase in focus, and can gain up to 30 minutes of sleep a night. Get up to $70 off an Apollo wearable; their biggest sale is happening now until the 15th.


Science & Technology

> International Space Station reportedly suffers its third coolant leak from a Russian-made laboratory module over the past year; cause of leak unclear (More)

> Analysis of skeletal remains overturns prevailing theory that the 1918 influenza pandemic was equally fatal for healthy adults, finds much higher mortality rates for frail or otherwise vulnerable victims (More) | Explore the global impact of the 1918 flu (More)

> Modified blue-green algae used in innovative new approach for faster wound-healing; bioactive film shown to kill bacteria, reduce inflammation, and speed cell regrowth (More)


Business & Markets

> US stock markets close higher (S&P 500 +0.5%, Dow +0.4%, Nasdaq +0.6%) for third consecutive session (More)

> Birkenstock prices initial public offering at $46 per share, valuing the sandal maker at nearly $9B; to start trading on the New York Stock Exchange today (More)

> General Motors reaches tentative labor agreement with Canadian auto workers union after workers started striking just after midnight yesterday morning (More)


Politics & World Affairs

> House GOP holds closed-door debate over next speaker, internal balloting to choose a nominee expected to begin tomorrow (More) | Majority Leader Steve Scalise (LA-1), Judiciary Committee Chair Jim Jordan (OH-4) top candidates; some lawmakers pushing to reinstate Rep. Kevin McCarthy (CA-20) (More)

> Rep. George Santos (R, NY-03) faces 10 new federal charges, including conspiracy, wire fraud, falsification of records, and aggravated identity theft; Santos already faces 13 federal charges to which he pleaded not guilty in May (More

> Finland says damage to undersea gas pipeline and telecommunications cables appears likely to be sabotage; line supplied a third of Finland's natural gas as of 2020 (More) | American Evan Gershkovich, Wall Street Journal reporter jailed by Russia on espionage charges, loses appeal, will stay in prison until at least through November (More)

In partnership with CARIUMA

'Most Comfortable Sneakers I Own'


So those Cariuma kicks we were talking about: Stylish. Comfortable. Versatile. Even better? They are BCorp certified, so you can feel good supporting them. Plus, they plant two trees in the Brazilian rainforest for every pair of sneakers sold. 


Get ahead of your holiday shopping for friends and family (and yourself). Check out the Cariuma OCA Low colors, patterns, and limited edition collabs, plus, snag a sweet 1440-exclusive 20% off with code 144020.

Please support our sponsors!


Pumpkin weighing 2,749 pounds breaks record for biggest gourd.


... and a Missouri man sets record for longest pumpkin boat journey.


See the winners of the panoramic photo awards.


A 128-year-old shipwreck is discovered in Lake Huron.


How often you should wash your jeans.


The world's most expensive spice is worth more than gold.


This year's best new bartenders in the US.


Cat caught acting naughty when he thinks he's alone.


Clickbait: San Francisco restaurants to fine brunch vomiters


Historybook: Earthquake in Aleppo, Syria, kills 230,000 people (1138); Eleanor Roosevelt born (1884); "Saturday Night Live" premieres (1975); Kathryn D. Sullivan becomes first American woman to perform a spacewalk (1984); ... and Alexei Leonov, first person to ever perform a spacewalk, dies (2019).

"You gain strength, courage, and confidence by every experience in which you really stop to look fear in the face."

- Eleanor Roosevelt

Why 1440? The printing press was invented around the year 1440, spreading knowledge to the masses and changing the course of history. More facts: In every day, there are 1,440 minutes. We’re here to make each one count.


Send us your feedback at [email protected] and help us stay as unbiased as humanly possible. We’re ready to listen.


Interested in reaching smart readers like you? To become a 1440 partner, apply here.

1440 Media 222 W Merchandise Mart Plaza, Suite 1212 Chicago, IL 60654

Copyright © 2023, 1440 Media, All rights reserved.


Join a community of over 3.6 million intellectually curious individuals.

100% free. Unsubscribe anytime.

Don't miss out on the daily email read by over 3.6 million intellectually curious readers.