Good morning. It's Wednesday, April 16, and we're covering an escalating fight in higher education, a green light for a first-of-its-kind clinical trial, and much more. First time reading? Join over 4 million intellectually curious readers. Sign up here.
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President Donald Trump yesterday suggested he could revoke Harvard's tax-exempt status and classify it as a political entity after the university said it wouldn't comply with requests to overhaul its policies and programs. Trump's comments came a day after his administration said it would freeze $2.26B of Harvard’s multiyear funding, highlighting a broader conflict over academic independence and federal oversight.
On Monday, Harvard—America's oldest and wealthiest university—became the first institution to openly reject a series of changes from the Trump administration, which claims such measures are necessary to combat antisemitism on campuses. The changes (see letter) include removing diversity, equity, and inclusion initiatives, adopting merit-based admissions and hiring practices, and banning identity-covering masks during student protests. Harvard said the requests infringed upon its independence; read the school's response here.
The Trump administration has similarly pressured at least six other universities, including Columbia University, which conceded to a list of reforms last month. Harvard has the largest endowment in the nation at $53B—about 20% of which can be spent at the school's discretion.
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The US Food and Drug Administration has approved the first clinical trial to test whether gene-edited pig livers can temporarily support people with sudden liver failure who are ineligible for human organ transplants. Instead of receiving a new liver, the patients will be connected to an external device that filters their blood through a pig liver for 72 hours, giving their own liver time to recover and hopefully regenerate.
The trial, led by biotech firm eGenesis and medical device maker OrganOx, will enroll up to 20 patients between the ages of 10 and 70 with acute-on-chronic liver failure (a sudden worsening of liver disease) or hepatic encephalopathy (a brain disorder caused by reduced liver function). Participants will be monitored for a year to assess safety and liver function changes. Earlier tests in the US using deceased patients showed the pig livers could function for two to three days.
Roughly 35,000 patients are hospitalized each year in the US for acute or acute-on-chronic liver failure, many of whom can’t get a timely human transplant.
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At least 3,700 people were hospitalized with respiratory issues in Iraq this week after a large sandstorm swept across the region from Saudi Arabia, filling the skies with an orange haze and reducing visibility to only half a mile. Much of Baghdad, including airports and highways, has been shut down since Sunday as the tiny particles forced people indoors.
Sand or dust storms occur in dry or drought-ridden regions like deserts or plains and valleys with substantial clay and silt deposits (see map). High wind speeds lift the particles and move them potentially hundreds of miles, reducing the sun’s light and heat. When inhaled, the fine particles can irritate the lungs, potentially leading to infections. Mechanical equipment is also vulnerable to corrosion and clogs from the dust.
Sandstorms have been common in Iraq for millennia, occurring weekly on average during peak seasons, though this week’s event is relatively severe. Read how a dust storm played a key role during the US invasion of the country here.
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Editor's note: Based on reader feedback we received yesterday on our report about Kilmar Abrego Garcia's deportation to El Salvador, we wanted to note there are conflicting reports about his alleged membership in the MS-13 gang and his legal status in the US. Read a breakdown here.
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In partnership with Pacaso
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Zillow’s Co-Founder Has a Big New Idea
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Spencer Rascoff co-founded Zillow, scaling it into a $16B real estate giant. But everyday investors couldn’t invest until after the IPO, missing early gains.
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You can join them for just $2.80/share. Even better? Their private stock isn’t subject to public market volatility. Become a Pacaso investor today.*
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Sports, Entertainment, & Culture
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> "Good Night, and Good Luck," starring George Clooney, hauls in $3.7M to break its own weekly box office record for a Broadway play (More)
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> Los Angeles' Dodger Stadium tapped as baseball venue for 2028 Summer Olympics as LA28 organizers unveil complete venue plan for Olympic Games (More)
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> Backstreet Boys' Nick Carter accused in lawsuit of sexual assault; Carter has now been accused by four women of sexual assault (More)
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> OpenAI reportedly considering its own social media platform to compete with Elon Musk's X, tied to its newest image-generation feature (More) | Everything you want to know about OpenAI (1440 Topics)
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> AI startup Anthropic's premium Claude chatbot now integrates with Google Workspace, enabling it to reference emails in Gmail, search documents in Google Docs, and schedule events in Google Calendar (More)
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> Brain imaging study reveals dogs with elongated brains exhibit stronger connections in olfactory brain regions than dogs with rounder-shaped brains, impacting their sense of smell (More)
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> US stock markets close lower (S&P 500 -0.2%, Dow -0.4%, Nasdaq -0.0%) (More) | Hewlett Packard Enterprise shares rise 5% after activist Elliott Investment Management takes $1.5B stake (More)
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> Johnson & Johnson says it expects $400M in tariff-related costs this year, mostly related to China (More) | Apple airlifted iPhones worth a record $2B from India last month as US tariffs loomed (More) | ... and China is reportedly ordering its airlines to stop accepting deliveries of Boeing jets in response to US import tariffs (More)
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> Federal judge scraps US Consumer Financial Protection Bureau rule capping credit card late fees at $8, says rule prevents card issuers from imposing fees that are proportionate to violations (More)
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In partnership with FinanceBuzz
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You could be wasting hundreds every year on overpriced insurance. The experts at FinanceBuzz believe they can help.
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> Measles cases linked to Texas outbreak rise to 561, with 20 new infections confirmed over the last five days and at least 58 people hospitalized so far, per new data from Texas health officials (More) | See nationwide CDC data (More)
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> Singapore dissolves Parliament, sets general elections for May 3; the People’s Action Party, which has ruled Singapore since the country's independence from Malaysia in 1965, is expected to maintain control (More)
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> US Justice Department unseals drug trafficking charges against two leaders of Mexican drug cartel La Nueva Familia Michoacana Organization, offering up to $8M for information leading to their arrest (More)
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In partnership with Pacaso
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Top Investors Are Buying This Unlisted Stock
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When the team that created Zillow and grew it to a $16B valuation starts a new company, investors notice. It’s no wonder top firms like SoftBank have already invested in Pacaso.
Taking the industry by storm all over again, Pacaso’s streamlined platform offers co-ownership of premier properties–revamping a $1.3T market. By handing keys to 2,000+ happy homeowners, Pacaso has made $100M+ in gross profits. Now, you can join them as an investor as they scale worldwide. Invest for $2.80/share today.*
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📖 This week's 1440 Topics newsletters:
1440 Business & Finance (Thursday)
Nvidia: How the company went from video games to a global AI leader (join here).
1440 Society & Culture (Saturday)
Professional Wrestling: From medieval grappling to Hulk Hogan and The Rock (join here).
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"The good and the great are only separated by the willingness to sacrifice."
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*Disclosure: This is a paid advertisement for Pacaso’s Regulation A offering. Please read the offering circular at invest.pacaso.com
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