Subscribe to the 1440 Daily Digest

The most impactful stories of the day, expertly curated and explained. 100% free, unsubscribe anytime.

Border Buildup, Bipolar Study, and the Year's Worst Cinema

In one of the largest-scale studies to date, researchers uncover dozens of genes linked to bipolar disorder that may help lead to new therapies and treatment. This and more in today's digest.

 

In partnership with

Good morning. It's Thursday, Jan. 23, and we're covering the Trump administration's push at the border, progress in understanding a major psychiatric disorder, and much more. First time reading? Join over 4 million intellectually curious readers. Sign up here.

Don’t keep us a secret: Share the email with friends (copy URL here)​.

And, as always, send us feedback at [email protected].

Need To Know
 

Border Buildup

Around 1,500 active-duty troops will be sent to the US-Mexico border in the coming days to assist with security measures, defense officials said yesterday. The move operationalizes one of President Donald Trump's central campaign promises—to stem the flow of migrants entering the country—and a declaration of national emergency he signed shortly after being sworn in Monday. 

 

Border Patrol reported roughly 100,000 migrant encounters in December (see data), a figure that is historically high but down from a record of more than 300,000 the year prior. The troops will join roughly 2,500 Army Reserve and National Guard personnel, though their specific tasks remain to be seen (federal troops are generally prohibited from domestic policing; see explainer). 

 

In related news, the Justice Department said it would shift focus to immigration priorities, including utilizing the FBI's terrorism task force to assist in efforts and ordering federal prosecutors to probe interference by state and local officials. 

 

Separately, Trump issued an order putting federal staff working in diversity, equity, and inclusion roles on paid leave as the administration seeks to eliminate the positions. See a list of orders and directives made by Trump since returning to office here.

 

Prince Harry Reaches Settlement

Prince Harry, Duke of Sussex, reached a settlement yesterday with Rupert Murdoch’s News Group Newspapers after accusing the company of unlawful gathering of private information. The decision to settle—which includes NGN's first-ever admission of wrongdoing on behalf of The Sun tabloid—concludes a six-year battle and avoids a lengthy court trial. 

 

Prince Harry filed the initial lawsuit in 2019 and vowed to take the case to trial to hold British media accountable for their alleged invasive practices, including hacking phones, hiring private detectives, and using deceptive methods. For years, NGN denied the allegations, which included intrusions into the prince's private life from 1996 to 2011. The apology also admitted to unlawful behavior by The Sun toward his late mother, Princess Diana, who died in 1997 while being pursued by paparazzi (read the full apology).

 

Murdoch's NGN has previously averted trials with lucrative payoffs in around 1,300 cases, spending over $1.2B on previous claims.

 

Bipolar Disorder Decoded

An international team of researchers has pinpointed 36 genes linked to bipolar disorder in the largest study conducted to date on the biological mechanisms underlying the condition. The findings could potentially help doctors intervene early and better diagnose and treat individuals at risk. 

 

Bipolar disorder (watch overview) is largely genetic, with an estimated heritability of around 80%, meaning there is a significant genetic predisposition to developing the chronic mental health condition. The disorder is characterized by intense mood swings between manic and depressive episodes, which can alter a person's energy levels, behavior, thinking patterns, and ability to function in daily life. Around 40 million to 50 million people worldwide experience bipolar disorder.

 

The findings also identified 298 genomic regions—specific locations in our DNA sequence—associated with bipolar disorder, of which 267 are newly discovered. Roughly 158,000 individuals with bipolar disorder and 2.8 million healthy individuals worldwide participated in the study. Learn more about genes here and DNA here.

In partnership with Timeline

A Scientific Breakthrough In Human Aging

 

The first signs of aging happen where you can’t see them—inside your cells. Beginning in your 30s, the mitochondria, responsible for 90% of your body’s energy, take on damage with time, and your cells slowly lose the ability to repair it. This decline wears down your energy and physical strength, leaving you feeling weak and fatigued.

 

Luckily, Swiss scientists have revealed a way to restore this process and support healthy aging. Mitopure®, a clinically proven longevity supplement, replaces aging mitochondria and helps to rebuild new ones, giving you your energy back. The results? Studies found participants saw energy and muscle strength increase without any changes to exercise.

 

Take aging into your own hands. 1440 readers can take 33% off Mitopure, while supplies last.

Please support our sponsors!

In The Know
 

Sports, Entertainment, & Culture

> 2025 Academy Awards nominations to be announced this morning (8:30 am ET); watch livestream here (More) | 2025 Sundance Film Festival kicks off today from Park City, Utah (More)

> Singer Chris Brown files $500M defamation lawsuit against Warner Bros., alleging he was falsely labeled a serial rapist and abuser in 2024 docuseries (More) | George Clinton, Mike Love, and Michael McDonald highlight 2025 inductees into the Songwriters Hall of Fame (More)

> SEC and Big Ten athletic directors to meet next month to discuss potential changes to College Football Playoff format, including expanding the field from 12 to 14 teams (More

 

Science & Technology

> Astronomers detect fast radio bursts—pulses of radiation typically from neutron stars or black holes—originating from a long dead galaxy; findings not explained by current understanding of the phenomena (More

> Study reveals immune cells perform unique and specialized functions within the gut depending on their location within the small intestine; discovery may lead to new ways to boost the immune system (More

> Cownose ray tails act as a finely tuned antenna to sense water movements, researchers discover; the function of the tail on many manta rays and related species was previously unknown (More

In partnership with Mode Mobile

Answer the Call on This Pre-IPO Opportunity

As Elon Musk put it, “Apple used to really bring out products that would blow people’s minds.” Those days, however, seem behind us. But a new smartphone company, boasting 32,481% revenue growth over three years, is filling that void. 

 

Mode turns phones into income streams, helping 45M+ users earn and save $325M+, driving $60M+ in revenue. They even recently reserved the Nasdaq ticker $MODE. Uber did it to taxis, Airbnb to hotels. And now, Mode is doing it to the $1T smartphone industry.

 

Join 30,000+ shareholders and invest at $0.26/share today.*

 
 

Business & Markets

> US stock markets close higher (S&P 500 +0.6%, Dow +0.3%, Nasdaq +1.3%); S&P 500 closes shy of record high as technology shares, including Oracle (+6.8%) and Nvidia (+4.4%) rise on artificial intelligence enthusiasm (More)

> Google invests additional $1B in generative AI startup Anthropic, bringing its total investment to over $3B and building on a previous 10% ownership stake (More

> Electronic Arts shares fall over 11% in after-hours trading after the video game giant slashes full-year bookings guidance due to underperforming games, particularly its soccer franchise (More)

 

Politics & World Affairs

> Seventeen-year-old male student fatally shoots female student and himself, wounds a male student in cafeteria of Antioch High School in Nashville; motive is unclear (More

> Hughes Fire—north of Santa Clarita in Los Angeles County—breaks out, burning more than 10,000 acres as of this writing (More) | See map of all fires (More) | Winter storm continues spreading across southern US; see record-breaking totals (More)

> Yemen's Houthi rebels release crew of vessel they captured in November 2023, a step toward ending Red Sea vessel attacks following Israel-Hamas ceasefire deal (More) | Iraq passes bill that critics say effectively legalizes child marriage (More

 

In-Depth

> Are We Losing the Ability to Write by Hand?

The Guardian | Christine Rosen. In a technology-driven world where digital devices have largely replaced handwriting, do we risk losing the cognitive and sensory benefits that come with it? (Read)

 

> Amarillo by Morning

Texas Highways | Emily Gogolak. While coping with the loss of her pet, Gogolak returns to the Texas Panhandle to repay a stranger who helped her while stranded on the side of the road. (Read)

In partnership with Timeline

Is Cellular Health The New Gut Health?

 

You’ve heard the mitochondria are the "powerhouses of your cells." Did you know these cellular structures also act as regulators of health as you age? But over time, your mitochondria's efficiency wanes, contributing to aging and risk of chronic disease.

 

Meet Mitopure®, a powerful healthy aging solution shown in clinical studies to significantly increase cellular energy and muscle strength, starting in as little as two months. Even better? The improvements were achieved without any change in exercise. Start your journey to more energy and stronger muscles today. 1440 readers get 33% off, while supplies last.

Please support our sponsors!

Etcetera
 

This year's Razzie nominees, celebrating the worst of cinema.

 

... and explaining the Grammy's best new artist category.

 

Turns out "bird brain" may not be an insult.

 

Court rules elephants cannot sue to leave the zoo.

 

"Bozo the Plown" leads Chicago’s snowplow naming contest.

 

... who was Bozo, The World's Most Famous Clown?

 

Mittens the cat becomes an accidental frequent flyer

 

Coors Light enters the skin care arena.

 

Clickbait: Thousands are waiting for a rare, stinky plant to bloom.

 

Historybook: American statesman John Hancock born (1737); The US and Vietnam reach peace settlement (1973); Athlete, artist, and activist Paul Robeson dies (1976); Salvador Dalí dies (1989); Madeleine Albright becomes first US female secretary of state (1997).

"Have no fear of perfection—you'll never reach it."

- Salvador Dalí

Why 1440? The printing press was invented around the year 1440, spreading knowledge to the masses and changing the course of history. More facts: In every day, there are 1,440 minutes. We’re here to make each one count.

*Disclosure: Please read the offering circular at invest.modemobile.com. This is a paid advertisement for Mode Mobile’s Regulation A Offering. A reservation of the ticker symbol is not a guarantee that we will be listed on the NASDAQ. Any IPO timing is unknown, general steps to be accepted have not been undertaken at this point, and that listing is not guaranteed.

1440 Media 222 W Merchandise Mart Plaza, Suite 1212 Chicago, IL 60654

Copyright © 2025, 1440 Media, All rights reserved.