Samuel O’Reilly patented the tattoo gun in 1891

Before the tattoo gun's invention, recipients sweated while artists slowly tapped or sliced designs into their flesh. The tattoo gun changed the field, helping artists ink clients’ skin at incredible speeds. Inventor Samuel O’Reilly applied the basic idea of an electric pen invented by Thomas Edison to his tattoo gun.

Watch the engineering challenges overcome in turning a 3D printer into a tattoo machine

The DIY project required reprogramming the printer to operate on a curved, 2D surface rather than making flat layers in 3D, editing replacement firmware to bypass temperature safety checks, and developing a rapid system to stop the tattoo in case of an emergency. The final product printed "LEG" on a volunteer's leg.

The first 3D printing patent was filed in 1967

Wyn Swainson, an English literature graduate student, filed a patent in Denmark for a system that scans an object and uses the scanning data to rebuild it using lasers that harden light-sensitive plastic. However, he never developed a working prototype. The idea originated from wanting to produce recreations of sculptures.

Harvard and MIT researchers are developing life-saving tattoos

Tattoos aren’t just a fashion statement. Scientists are trying to find life-saving applications for them. Harvard and MIT researchers are developing tattoo inks that react to body chemicals, alerting diabetics to blood sugar fluctuations or athletes to dehydration. Someday, patients may observe their body chemistry with tattoos that change colors.

'Magic ink' is redefining the tattoo

One University of Colorado professor has developed an ink that can be "turned on" with exposure to UV light, and "turned off" with sunlight. While the ink could help those who want to hide their body art from family members or coworkers, there are potential uses for medical procedures.

View a timeline of 3D printing technology through 2019

The first working 3D printing device was invented in 1983 and utilized stereolithography, a process in which a laser triggers a chemical reaction that hardens liquid resin. Powder-based laser sintering technology was patented in 1987, with metal-based powders first being used for 3D printing in 1997.

Technological breakthroughs are spurring innovations in the industry

What if you could see your tattoos before they’re embedded in your skin? Or take a virtual visit into a local studio to work out your nerves over a first tattoo? The industry is anticipating some big technological changes, from 3D designs to sci-fi upgrades to more precise tattoo guns.

Medical imaging allows 3D printers to create patient-matched devices

With imaging data on a person's anatomy, external prostheses and implants, such as cranial plates or hip joints, can be custom-printed to better match a patient's body. Fabrication of porous structures can promote bone growth, leading to longer-lasting implants.

How 3D printing inside cells paves the way for microscopic machines

In 2026, scientists in Slovenia developed a method to 3D print a small elephant, several microscopic geometric objects, and barcodes for cell labeling within living human cells, which continued to grow and divide thereafter. The experiment opens the door to fabricating devices within cells to study and manipulate cellular functions.

Hacking the body for a future that didn't happen

Journalist Adi Robertson experimented with one of the most accessible biohacks: magnets. Having a tiny magnet in their right ring finger meant they could sense magnetic fields, attract small metal objects, and more. But magnets weaken over time, eroding this new sense. Such implants do more than offer a new way of interacting with the world, they also pose new complications, such as the inability to get an MRI.

Experience a century of America's healthcare advances with this medical visualization, tracing a sampling of healthcare innovations from head to toe.

Tattoos, explained

Tattoos last because immune cells trap ink beneath the skin—but there's more to the story. This overview looks at how ancient cultures used tattoos for status, spirituality and punishment; how technology like the electric tattoo machine transformed the art form, and where innovations like smart tattoos could take it next.

Pig heart valves have been placed in humans since 1965

The first successful use of a pig heart valve in a human was reported in 1965. This 2015 video details why humans have been able to use pig animal valves for so long with good results and how that differs from what's needed for whole organ transplants.

Neuralink brain implants have enabled a paralyzed person to play video games

As one of twelve test subjects in Neuralink's PRIME study, Rob Greiner's implant translates his brain's activity into digital commands for the 'Battlefield 6' game. He can now also design 3D models and 3D-print objects using his thoughts.

Most custom earmolds for in-ear hearing aids are made using 3D printing

The technology has also been utilized for behind-the-ear and receiver-in-canal hearing aids, allowing for the creation of structures tailored to the patient's anatomy for enhanced effectiveness. 3D printing has also been used to print retinal eye cells and custom eyeglass frames.

Light therapy was widely used as a medical treatment for various maladies in the early 1900s before it was replaced by antibiotics.

How 'the Iceman' got his tattoos remains a mystery

Ötzi the Iceman, discovered in 1991, is one of the oldest human mummies ever found—and his 61 tattoos remain a mystery. This explainer looks at how researchers believe the tattoos were made, what their placement suggests about ancient medicine and culture, and why we’re still piecing together their true purpose today.

Penicillin’s pioneers were awarded the Nobel Prize in 1945

Alexander Fleming, Howard Florey, and Ernst Chain received the 1945 Nobel Prize in Physiology or Medicine for discovering and developing penicillin.

The first commercially successful calculating machine—the arithmometer—was patented in 1820 but not mass-produced for over three decades, likely because its inventor was focused on his insurance business.

Read more about the backstory on the 2025 Nobel Prize for immune system work

A trio of scientists won the Nobel in Physiology or Medicine that year, but they performed their award-worthy work beginning about two decades before winning the prize. This announcement includes details about the science and notes that the three scientists will equally share the 11 million Swedish kronor (almost $1.2M).

Oxford scientists turned Fleming’s mold discovery into medicine

In 1939, a team at Oxford—including Howard Florey, Ernst Chain, and Norman Heatley—revived Fleming’s forgotten discovery. Using makeshift equipment like bedpans and milk churns, they purified enough penicillin to prove it could treat deadly infections.

Brain implants are restoring movement and communication in early human trials

Several companies developing brain-computer interfaces have begun testing on humans with promising results. These implants have helped reanimate paralyzed limbs and enable communication, though ethical concerns remain about data privacy.

The world’s oldest tattoos belong to 'Iceman' Ötzi

Ötzi is the corpse of "the Iceman" found in the Alps along the Italian and Austrian border in 1991. His mummified body was covered with lines and crosses along the “hard-working” areas of his body, signifying their potential application for therapeutic pain management.

Microgravity environments improve the success of 3D bioprinting

Gravity can cause gaps, such as those in the chambers of a 3D-printed heart, to collapse before stem cells, hydrogels, and biochemicals bind together during the bioprinting process. Rather than Earth's surface, some bioprinting is done on the International Space Station, where defective organs are also printed to test treatment methods.

Benjamin Franklin advocated for the use of paper money and even engineered some key anticounterfeiting techniques used today.

With no textbooks or antibiotics, this WWI surgeon pioneered facial reconstruction

New Zealand surgeon Dr. Harold Gillies made extraordinary advances in the field of reconstructive surgery during World War I and after. This 36-minute NPR podcast interviews historian Lindsey Fitzharris, author of Gillie's biography, The Facemaker, charting how the good doctor reconstructed the faces of numerous soldiers in an age before antibiotics and plastic surgery as we know it today.

In a first, eye prosthesis has restored sight to macular generation patients

In a clinical trial, 27 of 32 participants with advanced macular degeneration regained enough vision to read books, food labels, and subway signs about a year after receiving a prosthetic retina device. This is the first device to restore functional vision to patients with incurable vision loss, though in this case they can only see in black and white, with no shades in between.

A dispute about the origin of twitching frog legs led to the invention of the first battery

Experiments by Luigi Galvani on exposed frog leg nerves showed activity when they were hung from iron railings and brass hooks, suggesting the existence of "animal electricity" that discharged when connected to metals. Alessandro Volta's voltaic pile, which stacked metals with an inorganic electrolyte, showed that electricity originates from chemical reactions.

A physician with a rare and deadly disease saved his own life by identifying an existing medication that he repurposed for his condition, and now he's using AI to try to do the same for other patients.

Credit for inventing the laser was fought over for nearly three decades

Although Theodore Maiman built the first working laser in 1960, Gordon Gould coined the term earlier. Charles Townes and Arthur Schawlow of Bell Labs filed a patent after Gould came up with the idea and name, but before Gould filed his patent.

The first successful organ transplant was performed in 1954

The successful kidney transplant procedure, at what's now-called Brigham and and Women's Hospital, ushered in a new medical era and gave hope to patients with organ failure. The recipient, 23-year-old Richard Herrick, lived eight more years after receiving the donated organ from his living twin brother, Ronald.

Elon Musk's Neuralink's N1 chip can wirelessly read brain signals from over 2,000 electrodes

The device is a battery-powered brain implant that transmits data via Bluetooth. Neuralink's near-term objectives for the device focus on unlocking new treatments for paralysis, neurological disorders, and some psychiatric conditions.

Read why one man agreed to get a pig kidney in 2025 to replace his own failing organ

The 68-year-old New Hampshire man told USA Today that a motivator for the experimental surgery was his belief that he was going to die anyway, and other people suffering from kidney disease could gain valuable insights. Yet the surgery bought him time—he lived 271 days with a pig organ and later received a human kidney transplant. Clinical trials began in 2026 to test the pig xenotransplants in more people.

The origin story of the Paralympic movement and its founder, Dr. Ludwig Guttmann

Dr. Ludwig Guttmann, the founder of the Paralympic movement, revolutionized the treatment of spinal injuries. His belief in the power of sports for rehabilitation led to the creation of the Paralympic Games, now celebrated every Olympic year. This in-depth article from The History Press details the life and achievements of Dr. Guttmann, and includes historical photos and videos of the veterans-turned-athletes whose lives he changed.

The history of contact lenses may have begun with Leonardo da Vinci, who developed a concept of vision correction based on placing a substance directly on the eye's surface.

In 2015, the FDA approved the first 3D-printed prescription tablet

Spritam, an epilepsy medication, had been too large and difficult to swallow, particularly due to its inability to dissolve easily. The new pill was designed with porous layers to enhance its dissolvability, paving the way for future 3D printing of drugs.

Neural implants blur the line between personal intention and machine execution

A key ethical dilemma—the contemplation conundrum—explores whether implants might misinterpret mere imagination as intent to act. Neuroscientists have found no brain signal that clearly marks when someone decides to act, making intent hard to detect in neurotechnological systems.

An essay exploring how living day-to-day with a brain implant helps restore a sense of identity

Companies like Neuralink are experimenting with volunteers who have lost control over their bodies. Many of the program's participants claim the most significant benefit from the tool is the ability to perform simple, mundane tasks, such as playing video games or shaking hands, rather than more obvious milestones like walking or eating. This essay explores what it's like, day to day, to use a brain implant.