11.7.2024

 

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Good morning. It's Thursday, Nov. 7, and we're covering the latest on the US election, new cancer research, and much more. First time reading? Join over 4 million intellectually curious readers. Sign up here.

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Need To Know
 

Blue Wall Falls

President-elect Donald Trump is on track to return to the White House with a decisive victory in the Electoral College and the popular vote—the first Republican to secure the popular vote since President George W. Bush in 2004.

 

Trump has earned 295 electoral votes as of this writing, flipping all three "blue wall" states—Pennsylvania, Wisconsin, and Michigan—an achievement he also made in 2016, the only Republican president to do so since 1988. He secured at least 72.6 million votes nationally to Vice President Kamala Harris' 67.9 million. See a map of the red shift here

 

Trump's victory kicks off a 75-day period in which his transition team will work to fill roughly 4,000 government positions with political appointees. Vice President Kamala Harris has meanwhile conceded the race, speaking publicly on the outcome yesterday. President Joe Biden is set to address the nation tonight.

 

Vote counting remains ongoing to determine control of the House, with dozens of races still uncalled as of this writing. Republicans have won control of the Senate. See more updates on congressional and down-ballot races here.

 

Cancer DNA Therapy

A form of cancer-driving DNA was found to be much more prevalent in the cells of certain cancers, according to research released yesterday. The studies could pave a path toward targeted drug therapy for aggressive cancers of the brain, breast, and more. 

 

The research analyzed extrachromosomal DNA, atypical groups of genes located off the main 23 chromosome pairs of DNA inside each cell nucleus. In a study of 15,000 cancer patients hosting 39 types of tumors, researchers found 17% of tumors contained the genetic loops, more than previously thought. They also found ecDNA presence in tumors was associated with malignancy and greater fatality rates due to the unique—and theory-shifting—way ecDNA is passed on unequally during cell division. See the studies here.

 

In small-scale trials, researchers found ecDNA-laced tumor cells in mice were reduced after inhibiting the functions of a key protein known as CHK1. Early-phase clinical trials using CHK1 inhibitors on humans are underway.

 

Rafael Strikes Cuba

Hurricane Rafael made landfall in western Cuba yesterday as a Category 3 storm, with maximum sustained winds near 115 mph. Rafael is the fifth major hurricane of the Atlantic season, which runs from June through November.

 

The storm appeared to herald a nationwide blackout weeks after the country was hit by Hurricane Oscar and beset by days of power outages (see previous write-up). In the hours leading up to Rafael's landfall, the storm rapidly intensified, gaining 55 mph over 24 hours. Warnings of storm surges, flash flooding, and mudslides were in effect.

 

Rafael is the strongest storm to impact the northwestern Caribbean this late in the Atlantic hurricane season since 2009. It is set to continue its path in the Gulf of Mexico today and could make landfall in central Louisiana later this week or avoid a US landfall altogether. Track its path here.

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In The Know
 

Sports, Entertainment, & Culture

> Viewership of primetime coverage for presidential election across major networks and cable news channels falls to 42.3 million viewers, down 26% from 2020; lowest percentage of households follow TV coverage since 1960 (More

> Ruby slippers from "The Wizard of Oz" up for auction nearly 20 years after being stolen from Minnesota museum; the Judy Garland-worn slippers are expected to fetch more than $1M at auction (More

> Netflix confirms 2025 release for fifth and final season of "Stranger Things" (More) | Argentine police are investigating three people as part of probe into One Direction's Liam Payne's Oct. 16 death (More)

 

Science & Technology

> Ride-hailing platform Lyft to partner with trio of self-driving car startups to bring autonomous rides to Atlanta by next year (More

> Astronomers link fast radio bursts—high-energy spikes in radio waves lasting a few seconds or less—to massive star-forming galaxies; likely sources include magnetars, dead stars believed to emit universe's strongest magnetic fields (More

> Vampire bat metabolismunique among mammals, mirrors that of blood-sucking insects, new study finds; the animal has evolved to subsist on diets composed almost entirely of blood (More

 

Business & Markets

> US stock markets close higher (S&P 500 +2.5%, Dow +3.6%, Nasdaq +3.0%) following election; Dow notches record close in best day since 2022 (More) | Bitcoin hits all-time high, surpassing $75K (More) | Federal Reserve expected to cut interest rates today for the second time this year (More

> Tesla shares close up 15% at record high on expectations CEO Elon Musk and EV company will benefit from Trump presidency (More) | Toyota reports first drop in quarterly profit in two years following certification scandal and recalls (More

> Super Micro shares continue to fall, closing down 18% after issuing weaker-than-expected unaudited financial results amid accusations of accounting irregularities (More)

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Politics & World Affairs

> Justice Department works to wind down two federal criminal cases against President-elect Donald Trump—related to Jan. 6 and classified documents storage—in alignment with longstanding policy not to prosecute a sitting president (More)

> German Chancellor Olaf Scholz calls vote of confidence in his government for January 2025, potentially ushering in early elections; announcement comes after Scholz dismissed his finance minister over disagreements on economic reforms, endangering ruling centrist coalition (More)

> Moldovan President Maia Sandu wins reelection against pro-Russian candidate in second round of voting, with eligible voter turnout at 54% (More)

 

In-Depth

> Bustling Through the Physics of Crowds

Knowable Magazine | Matthew R. Francis and Maki Naro. How physicists apply learnings from the field of fluid dynamics to better structure stadiums, train stations, and more. (Read, w/graphics)

> How to Recover from a Bad Night of Sleep

NPR | Staff. Best practices for how to recover from a poor night of sleep—including tips for falling back asleep in the middle of the night and preparing for restorative sleep first thing in the morning. (Listen)

In partnership with hear.com

Don’t Your Ears Deserve The Best?

 

The biggest breakthrough in hearing aids is finally here. Designed by top German engineers, the Horizon IX by hear.com is the world’s first dual processing hearing aid (aka: it mutes background noise for unparalleled clarity). 

 

The Horizon IX is also nearly invisible, so you can enjoy perfect hearing without clunky, uncomfortable hearing aids. See if you qualify for a 45-day no-risk trial of the Horizon IX and join 400,000 hearing (and living) better! Click "hear".

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Etcetera
 

Why the research on the benefits of alcohol remains murky

 

First snow arrives on Mount Fuji to end record-breaking delay.

 

Photos showcasing this year's vibrant fall foliage.

 

Mysterious song identified in an internet-gripping mystery.

 

A look at the coolest hotels in America.

 

Roman-era skeleton is a mix of bones from five people spanning 2,500 years.

 

New technology can spot plastic on beaches from space.

 

Starbucks reveals holiday menu for 2024.

 

Clickbait: Did Turkey name the turkey—or did the turkey name Turkey?

 

Historybook: Nobel Prize-winning physicist and chemist Marie Curie born (1867); Jeannette Rankin becomes first woman elected to US Congress (1916); Evangelist Billy Graham born (1918); Eleanor Roosevelt dies (1962); Earvin "Magic" Johnson announces HIV-positive diagnosis (1991).

"Talent is never enough. With few exceptions the best players are the hardest workers."

- Earvin "Magic" Johnson

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